序列:MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
Ubiquitination is a posttranslational modification (PTM) which targets proteins for a variety of processes, such as proteasomal degradation, ER-associated degradation and intracellular traffficking. The ubiquitin (Ub) monomers form a chain in which its C-terminal Gly can be linked to any of the seven available Lys side chains or the N-terminus of the preceding Ub, yielding a large diversity of polyUb chains. Dha-based diubiquitin probes are highly useful in probing the deubiquitinase (DUB) activity and ubiquitin chain linkage specificity