生物反应系统(Biological reaction system)

生物反应系统是目前针对任何微生物发酵工艺最先进的解决方案。

The best solution for any microbial fermentation process.

无论是个体发酵或多级发酵系统，和信采用卫生无菌设计的设备以满足客户的最高要求，并符合国家(GMP)及国际(cGMP/FDA)药品标准。

Whether for single fermenters or multi-stage fermentation systems, sterile design and hygienically designed components are applied to meet the customer's highest requirements and comply with national (GMP) and international (cGMP/FDA) pharmaceutical standards.

该工艺在质量、准确性和重复性方面都非常优秀，具体是通过采用精密仪器控制PH值、PO₂、温度、搅拌速度和重量的方法来实现的。全面的工厂调试使得现场项目能够快速启动。

_{Excellent process result in terms of quality, accuracy and repeatability which is granted by controlling PH, PO2, temperature, agitator speed and weight through precise instrumentation. The complete Factory Acceptance Test (FAT) in the plant enables a quick start-up at site.}

生物反应器具有在常温常压下操作要求能防染菌并且能蒸汽灭菌，制作材质对微生物或酶无毒害; 酶常因底物浓度也不能太高，因而反应器体积相当庞大; 反应前需接入菌种，为防止杂菌污染和活性衰退，一般采用分批釜式反应器;在发酵过程中，常是气、液、固三相并存，流变学性质复杂，使采用化学反应工程的原理和方法，解决生物反应器的设计放大问题存在较大困难。

The bioreactor is operated at normal temperature and pressure and is required to prevent contamination and be resistant to steam sterilization. The material is non-toxic to microorganisms or enzymes. The substrate concentration cannot be too high, so the reactor volume is quite large. Before the reaction, it needs to be connected with the bacteria. In order to prevent contamination by bacteria and activity decline, the batch reactor is generally used. During the fermentation, gas, liquid and solid often coexist, and the rheological properties are complex, so that it is difficult to solve the problem of scaling up the design of bioreactors by using the principles and methods of chemical reaction engineering.

因此，生物反应器具有耐受蒸汽灭菌、反应时常是气、液、固三相并存、能防止杂菌污染和活性衰退、常温常压下操作、制作严密无隙以防染菌、反应器体积相当庞大、对微生物或酶无毒害的材质制作等特点。

Therefore, the bioreactor has such features as resistant to steam sterilization, coexistence of gas, liquid and solid during the reaction, being able to prevent contamination by bacteria and activity decline, operated at normal temperature and pressure, made tightly and seamlessly to prevent contamination by bacteria, quite large reactor volume, made of materials non-toxic to microorganisms or enzymes, etc.