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Chemical Properties
Molecular Weight:
532.56
Density:
1.229g/cm3
Boiling Point:
572.1°Cat760mmHg
Flash Point:
299.8°C
Biological Activity:
Potent, ATP-competitive VEGFR, PDGFR β and KIT inhibitor (K i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR β and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.
Safety Data of 341031-54-7
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