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Appearance:
White to light yellow crystal powder
Molecular Weight:
225.20464
Density:
1.77
Boiling Point:
595 °C at 760 mmHg
Melting Point:
256-257℃
Flash Point:
595 °C at 760 mmHg
Storage Temperature:
?20°C
Solubility:
** solubility: 0.7 mg/mL
Biological Activity:
Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC 50 values are 0.85 and 0.86 μ M respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
Stability:
Stable. Incompatible with strong oxidizing agents.
Usage:
Orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral
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