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Chemical Properties
Appearance:
White solid
Molecular Weight:
404.54
Density:
1.12 g/cm3
Boiling Point:
559.2 oC at 760 mmHg
Melting Point:
175℃
Flash Point:
185.3 oC
Storage Temperature:
2-8°C
Refractive index:
320 ° (C=0.5, CH3CN)
Solubility:
0.0004 mg/mL at 25 oC
Biological Activity:
Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
Usage:
An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase
Safety Data of 75330-75-5
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